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Given the current situation, we understand that people may experience worry and even fear about how their disease and treatment may impact their personal risk. Sanofi Genzyme is committed to patient safety and to transparent communication. We are taking COVID-19 seriously, and we are committed to updating the communities we serve with relevant information related to our medicines to help inform health decisions.

As COVID-19 has emerged only recently, there are no available data regarding the impact of the virus on our current therapies. At this time, if you have general questions about our therapies, you should consult the current U.S Prescribing Information (USPI).

Each patient’s situation is unique, and patients and their healthcare providers are in the best position to make decisions regarding their care. In addition to local public health authority guidance, and local guidance from medical or patient associations, more information about COVID-19 can be found on the Centers for Disease Control’s (CDC) website or the World Health Organization’s (WHO) website.

MAT-US-2001107

INDICATION

AUBAGIO® (teriflunomide) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Do not take AUBAGIO if you have severe liver problems, are pregnant or of childbearing potential and not using effective birth control, have had an allergic reaction to AUBAGIO or leflunomide, or are taking a medicine called leflunomide for rheumatoid arthritis. View IMPORTANT SAFETY INFORMATION

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WATCH REAL PEOPLE TALK about putting
their relapsing MS in the background

Patient Portrayal

AUBAGIO is a once-daily pill that could help put relapsing MS in the background.

AUBAGIO (teriflunomide) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

AUBAGIO® (teriflunomide): One pill, once a day relapsing MS treatment

Take AUBAGIO anywhere, with
or without food.
Taking AUBAGIO is one way you may be able to help put your relapsing MS in the background. Learn more about AUBAGIO’S EFFECTIVENESS.

Your healthcare provider will run certain tests before you start treatment. Once on AUBAGIO, your healthcare provider will monitor your liver enzyme levels monthly for the first 6 months.

Evaluating your treatment options can be overwhelming.
This guide could help.

Image of once-daily AUBAGIO tablet

WHO CAN TAKE AUBAGIO?

Your choice of treatment is personal.

You work hard to manage your relapsing MS, and your treatment should work just as hard. For your first treatment, you and your doctor want to be as comfortable as possible with your decision. If you’re already on a treatment, this experience will help you and your doctor decide what to do. Wherever you are in your journey, AUBAGIO is an option that may help put your relapsing MS in the background.

Talk to your healthcare provider about whether AUBAGIO is right for you. Not sure what to say? Download the discussion guide.

Is it time to reevaluate your current relapsing MS treatment?

visit exploring treatment

Patient Portrayal

How Aubagio works

Exploring the science behind AUBAGIO.

MS is thought to occur when a distinct set of immune cells become destructive and attack the central nervous system, specifically targeting the outer covering of the nerves known as the myelin sheath. When you take AUBAGIO it blocks an enzyme that’s needed for these cells to multiply. Blocking this enzyme is like a dimmer switch that dials down the cell’s ability to multiply. While we don’t fully understand how AUBAGIO works in relapsing MS, we do know that it works differently from other relapsing MS medicines.

Multiplying destructive immune cells in Relapsing Multiple Sclerosis

When you have relapsing MS, certain immune cells in your body become destructive and multiply.

AUBAGIO blocks the DHODH enzyme.

AUBAGIO blocks an enzyme called DHODH that these destructive cells need to keep multiplying.

AUBAGIO reduces the number of destructive immune cells that are thought to cause MS attacks.

Taken daily, AUBAGIO reduces the number of immune cells, including destructive immune cells that are thought to cause MS flare-ups, while still allowing normal immune cell activity to occur.

For illustrative purposes only.

Dosing comparison guide

You have options. How you take and how often you take your relapsing MS treatment may influence your decision on which treatment is right for you. See the comparison chart below and talk with your doctor about what would work best for you.

RELAPSING MS
TREATMENT OPTIONS
DOSING SCHEDULE
AUBAGIO®
(teriflunomide)
Once-daily tablet
AVONEX®
(interferon beta-1a)
Once-weekly injection
BETASERON®/EXTAVIA®
(interferon beta-1b)
3x-a-week injection
COPAXONE® 20/40mg
(glatiramer acetate injection)
Once-daily/3x-a-week injection
GILENYA®
(fingolimod)
Once-daily capsule
GLATOPA® 20/40mg
(glatiramer acetate injection)
Once-daily/3x-a-week injection
LEMTRADA®
(alemtuzumab)
2 rounds of infusions:
Round 1: 5 infusions;
Round 2: 3 infusions
MAVENCLAD®
(cladribine)
Year 1 – First dose: 4-10 pills for 1 week. Second dose: 23 to 27 days after first dose, another 4-10 pills

Year 2 – Third dose: 43 weeks after second dose, 4-10 pills. Fourth dose: 23 to 27 days after third dose, another 4-10 pills
MAYZENT®
(siponimod)
5-Day titration then one 2mg pill per day
OR
4-Day titration then one 1mg pill per day
(depending on CYP2C9 Genotype)
NOVANTRONE®
(mitoxantrone)
One infusion
every 3 months
OCREVUS®
(ocrelizumab)
2 initial infusions;
then 1 infusion
every 6 months
PLEGRIDY®
(peginterferon beta-1a)
One injection
every 2 weeks
REBIF®
(interferon beta-1a)
3x-a-week injection
TECFIDERA®
(dimethyl fumarate)
2x-a-day capsules
TYSABRI®
(natalizumab)
Once-a-month infusion
VUMERITY®
(diroximel fumarate)
2 capsules 2x-a-day

Trademarks are the property of their respective owners.

INDICATION

AUBAGIO® (teriflunomide) is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

IMPORTANT SAFETY INFORMATION

DO NOT TAKE AUBAGIO IF YOU:
  • Have severe liver problems. AUBAGIO may cause serious liver problems, which can be life-threatening. Your risk may be higher if you take other medicines that affect your liver. Your healthcare provider should do blood tests to check your liver within 6 months before you start AUBAGIO and monthly for 6 months after starting AUBAGIO. Tell your healthcare provider right away if you develop any of these symptoms of liver problems: nausea, vomiting, stomach pain, loss of appetite, tiredness, yellowing of your skin or whites of your eyes, or dark urine.
  • Are pregnant. AUBAGIO may harm an unborn baby. You should have a pregnancy test before starting AUBAGIO. After stopping AUBAGIO, continue to use effective birth control until you have made sure your blood levels of AUBAGIO are lowered. If you become pregnant while taking AUBAGIO or within 2 years after stopping, tell your healthcare provider right away and enroll in the AUBAGIO Pregnancy Registry at 1‑800‑745‑4447, option 2.
  • Are pregnant. AUBAGIO may harm an unborn baby. You should have a pregnancy test before starting AUBAGIO. After stopping AUBAGIO, continue to use effective birth control until you have made sure your blood levels of AUBAGIO are lowered. If you become pregnant while taking AUBAGIO or within 2 years after stopping, tell your healthcare provider right away and enroll in the AUBAGIO Pregnancy Registry at 1-800-745-4447, option 2.
  • Are of childbearing potential and not using effective birth control.

    It is not known if AUBAGIO passes into breast milk. Your healthcare provider can help you decide if you should take AUBAGIO or breastfeed — you should not do both at the same time.

    If you are a man whose partner plans to become pregnant, you should stop taking AUBAGIO and talk with your healthcare provider about reducing the levels of AUBAGIO in your blood. If your partner does not plan to become pregnant, use effective birth control while taking AUBAGIO.

  • Have had an allergic reaction to AUBAGIO or a medicine called leflunomide.
  • Take a medicine called leflunomide for rheumatoid arthritis.

AUBAGIO may stay in your blood for up to 2 years after you stop taking it. Your healthcare provider can prescribe a medicine that can remove AUBAGIO from your blood quickly.

Before taking AUBAGIO, talk with your healthcare provider if you have: liver or kidney problems; a fever or infection, or if you are unable to fight infections; numbness or tingling in your hands or feet that is different from your MS symptoms; diabetes; serious skin problems when taking other medicines; breathing problems; or high blood pressure. Your healthcare provider will check your blood cell count and TB test before you start AUBAGIO. Talk with your healthcare provider if you take or are planning to take other medicines (especially medicines for treating cancer or controlling your immune system), vitamins or herbal supplements.

AUBAGIO may cause serious side effects, including: reduced white blood cell count — this may cause you to have more infections; numbness or tingling in your hands or feet that is different from your MS symptoms; allergic reactions, including serious skin problems; breathing problems (new or worsening); and high blood pressure. Patients with low white blood cell count should not receive certain vaccinations during AUBAGIO treatment and 6 months after.

Tell your doctor if you have any side effect that bothers you or does not go away.

The most common side effects when taking AUBAGIO include: headache; diarrhea; nausea; hair thinning or loss; and abnormal liver test results. These are not all the side effects of AUBAGIO. Tell your healthcare provider about any side effect that bothers you.

Consult your healthcare provider if you have questions about your health or any medications you may be taking, including AUBAGIO.

Please click here for full Prescribing Information, including boxed WARNING and Medication Guide.

IMPORTANT SAFETY INFORMATION
Do not take AUBAGIO if you have severe liver problems. AUBAGIO may cause serious liver problems, which can be life-threatening. Your risk may be higher if you take other medicines that affect your liver. View More